Trace Elements, Antioxidant Enzymes and Free Carnitine Levels Among Epileptic Patients Treated with Valproate Monotherapy
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منابع مشابه
Supplementation with carnitine reduces the severity of constipation: a retrospective study of patients with severe motor and intellectual disabilities
Carnitine is an essential nutrient for the mitochondrial transport of fatty acids. Carnitine deficiency causes a variety of symptoms in multiple organs. Patients with severe motor and intellectual disabilities often have carnitine deficiency. This study aimed to determine the correlation between constipation and carnitine deficiency in them. Patients with severe motor and intellectual disabilit...
متن کاملAlterations in the carnitine metabolism in epileptic children treated with valproic acid.
Serum concentrations of total carnitine, free carnitine and acylcarnitine were measured in forty-one epileptic patients treated with valproic acid (VPA). Among them, 14 patients were on VPA monotherapy and 27 were on VPA polytherapy. Forty-one age and sex matched healthy normal controls were also evaluated for carnitine metabolism. The mean total and free carnitine were significantly lower in b...
متن کاملP-15: Effect of Consumption of Korean Red Ginseng and Sodium Valproate on Apoptosis of Spermatogenic Cells and Sperm Quality in Pilockarpin-Induced Epilepsy Rat Model
Background Reproductive dysfunction and endocrine disorders are common among men with complex partial seizures of temporal lobe origin. Diminished sexual desire and responsiveness along with decreased libido and less orgasm are frequently described in men with temporal lobe epilepsy (TLE). It appears that the reduced fertility in epileptic men is accompanied by erectile dysfunction and abnormal...
متن کاملEffects of Topiramate Vs Valproate on Serum Leptin and Lipid Peroxidation in Epileptic Patients
Aims: To assess and compare the body mass index (BMI), serum leptin, and lipid peroxidation represented by serum malondialdehyde (MDA) levels in epileptic patients on valproate (VPA) and topiramate (TPM) monotherapy for at least 6 months taking in consideration dosage and duration of therapy, in comparison to healthy controls. Methods: A cross-sectional, case-series study design was adopted, fo...
متن کاملSerum carnitine levels in ambulatory epilepsy outpatients
Carnitine deficiency related to epilepsy or antagonism of carnitine by antiepileptic drugs (AEDs) has attracted increasing attention since the first recognition of a neuromuscular deficiency syndrome in 1973’. Carnitine deficiency is linked to the potentially fatal hepatotoxicity that occasionally attends valproate therapy, particularly in children2, and has been documented in adult and pediatr...
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تاریخ انتشار 2017